Functional conservation of MBD proteins: MeCP2 and Drosophila MBD proteins alter sleep.

ABSTRACT: Proteins containing a methyl-CpG-binding domain (MBD) bind 5mC and convert the methylation pattern information into appropriate functional cellular states. The correct readout of epigenetic marks is of particular importance in the nervous system where abnormal expression or compromised MBD protein function, can lead to disease and developmental disorders. Recent evidence indicates that the genome of Drosophila melanogaster is methylated and two MBD proteins, dMBD2/3 and dMBD-R2, are present. Are Drosophila MBD proteins required for neuronal function, and as MBD-containing proteins have diverged and evolved, does the MBD domain retain the molecular properties required for conserved cellular function across species? To address these questions, we expressed the human MBD-containing protein, h

SUBMITTER: Gupta T 

PROVIDER: S-EPMC5118191 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature