Prediction of non-recovery from ventilator-demanding acute respiratory failure, ARDS and death using lung damage biomarkers: data from a 1200-patient critical care randomized trial.

ABSTRACT:

Background

It is unclear whether biomarkers of alveolar damage (surfactant protein D, SPD) or conductive airway damage (club cell secretory protein 16, CC16) measured early after intensive care admittance are associated with one-month clinical respiratory prognosis. If patients who do not recover respiratory function within one month can be identified early, future experimental lung interventions can be aimed toward this high-risk group. We aimed to determine, in a heterogenous critically ill population, whether baseline profound alveolar damage or conductive airway damage has clinical respiratory impact one month after intensive care admittance.

Methods

Biobank study of biomarkers of alveolar and conductive airway damage in intensive care patients was conducted. This was a

SUBMITTER: Jensen JS 

PROVIDER: S-EPMC5118375 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature