Finding Potential Therapeutic Targets against Shigella flexneri through Proteome Exploration.

ABSTRACT: Background:Shigella flexneri is a gram negative bacteria that causes the infectious disease "shigellosis." S. flexneri is responsible for developing diarrhea, fever, and stomach cramps in human. Antibiotics are mostly given to patients infected with shigella. Resistance to antibiotics can hinder its treatment significantly. Upon identification of essential therapeutic targets, vaccine and drug could be effective therapy for the treatment of shigellosis. Methods: The study was designed for the identification and qualitative characterization for potential drug targets from S. flexneri by using the subtractive proteome analysis. A set of computational tools were used to identify essential proteins those are required for the survival of S. flexneri. To

SUBMITTER: Hossain MU 

PROVIDER: S-EPMC5118456 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature