IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases.

ABSTRACT: The T_H17 immune response has a central role in the pathogenesis of autoimmune diseases, implicating the T_H17 master cytokine, IL-17A, as the critical mediator of diseases such as human and experimental crescentic GN. However, the relative importance of additional T_H17 effector cytokines, including IL-17F, in immune-mediated tissue injury remains to be fully elucidated. Here, using a mouse model of acute crescentic GN (nephrotoxic nephritis), we identified CD4⁺ T cells and γδ T cells as the major cellular source of IL-17F in the inflamed kidney. Interventional studies using IL-17F gene-deficient mice, IL-17F-neutralizing antibodies, and adoptive transfer experiments into Rag1^-/- mice demonstrated that CD4⁺ T cell-derived IL-1

SUBMITTER: Riedel JH 

PROVIDER: S-EPMC5118482 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature