Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.

ABSTRACT: Pendrin is a Cl^-/HCO₃^- exchanger expressed in type B and non-A, non-B intercalated cells in the distal nephron, where it facilitates Cl^- absorption and is involved in Na⁺ absorption and acid-base balance. Pendrin-knockout mice show no fluid-electrolyte abnormalities under baseline conditions, although mice with double knockout of pendrin and the Na⁺/Cl^- cotransporter (NCC) manifest profound salt wasting. Thus, pendrin may attenuate diuretic-induced salt loss, but this function remains unconfirmed. To clarify the physiologic role of pendrin under conditions not confounded by gene knockout, and to test the potential utility of pendrin inhibitors for diuretic therapy, we tested in mice a small-molecule pendrin inhibi

SUBMITTER: Cil O 

PROVIDER: S-EPMC5118489 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature