Metabolic Profiling of Impaired Cognitive Function in Patients Receiving Dialysis.

ABSTRACT: Retention of uremic metabolites is a proposed cause of cognitive impairment in patients with ESRD. We used metabolic profiling to identify and validate uremic metabolites associated with impairment in executive function in two cohorts of patients receiving maintenance dialysis. We performed metabolic profiling using liquid chromatography/mass spectrometry applied to predialysis plasma samples from a discovery cohort of 141 patients and an independent replication cohort of 180 patients participating in a trial of frequent hemodialysis. We assessed executive function with the Trail Making Test Part B and the Digit Symbol Substitution test. Impaired executive function was defined as a score ≥2 SDs below normative values. Four metabolites-4-hydroxyphenylacetate, phenylacetylglutamine, hippurat

SUBMITTER: Kurella Tamura M 

PROVIDER: S-EPMC5118491 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature