Photo-decomposable Organic Nanoparticles for Combined Tumor Optical Imaging and Multiple Phototherapies.

ABSTRACT: Combination of photodynamic therapy (PDT) with photothermal therapy (PTT) has achieved significantly improved therapeutic efficacy compared to a single phototherapy modality. However, most nanomaterials used for combined PDT/PTT are made of non-biodegradable materials (e.g., gold nanorods, carbon nanotubes, and graphenes) and may remain intact in the body for long time, raising concerns over their potential long-term toxicity. Here we report a new combined PDT/PTT nanomedicine, designated SP³NPs, that exhibit photo-decomposable, photodynamic and photothermal properties. SP³NPs were prepared by self-assembly of PEGylated cypate, comprising FDA-approved PEG and an ICG derivative. We confirmed the ability of SP³NPs to generate both singlet oxygen for a photody

SUBMITTER: Miao W 

PROVIDER: S-EPMC5118601 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature