Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC.

ABSTRACT: Cellular turgor is of fundamental importance to bacterial growth and survival. Changes in external osmolarity as a consequence of fluctuating environmental conditions and colonization of diverse environments can significantly impact cytoplasmic water content, resulting in cellular lysis or plasmolysis. To ensure maintenance of appropriate cellular turgor, bacteria import ions and small organic osmolytes, deemed compatible solutes, to equilibrate cytoplasmic osmolarity with the extracellular environment. Here, we show that elevated levels of c-di-AMP, a ubiquitous second messenger among bacteria, result in significant susceptibility to elevated osmotic stress in the bacterial pathogen Listeria monocytogenes. We found that levels of import of the compatible solute carnitine show an inverse c

SUBMITTER: Huynh TN 

PROVIDER: S-EPMC5118871 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature