Conservation of immune gene signatures in solid tumors and prognostic implications.

ABSTRACT:

Background

Tumor-infiltrating leukocytes can either limit cancer growth or facilitate its spread. Diagnostic strategies that comprehensively assess the functional complexity of tumor immune infiltrates could have wide-reaching clinical value. In previous work we identified distinct immune gene signatures in breast tumors that reflect the relative abundance of infiltrating immune cells and exhibited significant associations with patient outcomes. Here we hypothesized that immune gene signatures agnostic to tumor type can be identified by de novo discovery of gene clusters enriched for immunological functions and possessing internal correlation structure conserved across solid tumors from different anatomic sites.

Methods

We assembled microarray expression datasets encompassin

SUBMITTER: Chifman J 

PROVIDER: S-EPMC5118876 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature