Ficolin-2 inhibitors are present in sera after prolonged storage at -80 °C.

ABSTRACT: Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation. Baseline inflammation increases with aging in a phenomenon known as "inflammaging." Although IL-6 and C-reactive protein are known to increase with age, contributions of many complement factors, including ficolins, to inflammaging have been little studied. Ficolin-2 is abundant in human serum and can recognize many target structures; therefore, ficolin-2 has potential to contribute to inflammaging. We hypothesized that inflammaging would alter ficolin-2 levels among older adults and examined 360 archived sera collected from older individuals. We found that these sera had apparently reduced ficolin-2

SUBMITTER: Geno KA 

PROVIDER: S-EPMC5119277 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature