A microarray whole-genome gene expression dataset in a rat model of inflammatory corneal angiogenesis.

ABSTRACT: In angiogenesis with concurrent inflammation, many pathways are activated, some linked to VEGF and others largely VEGF-independent. Pathways involving inflammatory mediators, chemokines, and micro-RNAs may play important roles in maintaining a pro-angiogenic environment or mediating angiogenic regression. Here, we describe a gene expression dataset to facilitate exploration of pro-angiogenic, pro-inflammatory, and remodelling/normalization-associated genes during both an active capillary sprouting phase, and in the restoration of an avascular phenotype. The dataset was generated by microarray analysis of the whole transcriptome in a rat model of suture-induced inflammatory corneal neovascularisation. Regions of active capillary sprout growth or regression in the cornea were harvested and t

SUBMITTER: Mukwaya A 

PROVIDER: S-EPMC5119432 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature