Incontinence medication response relates to the female urinary microbiota.

ABSTRACT:

Introduction and hypothesis

Many adult women have resident urinary bacteria (urinary microbiome/microbiota). In adult women affected by urinary urgency incontinence (UUI), the etiologic and/or therapeutic role of the urinary microbiome/microbiota remains unknown. We hypothesized that microbiome/microbiota characteristics would relate to clinically relevant treatment response to UUI medication per os.

Methods

Adult women initiating medication treatment orally for UUI and a comparator group of unaffected women were recruited in a tertiary care health-care system. All participants provided baseline clinical data and urine samples. Women with UUI were given 5 mg solifenacin, with potential dose escalation to 10 mg for inadequate UUI symptom control at 4 weeks. Additional data an

SUBMITTER: Thomas-White KJ 

PROVIDER: S-EPMC5119460 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature