The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models.

ABSTRACT: Microfluidic human organ models, microphysiology systems (MPS), are currently being developed as predictive models of drug safety and efficacy in humans. To design and validate MPS as predictive of human safety liabilities requires safety data for a reference set of compounds, combined with in vitro data from the human organ models. To address this need, we have developed an internet database, the MPS database (MPS-Db), as a powerful platform for experimental design, data management, and analysis, and to combine experimental data with reference data, to enable computational modeling. The present study demonstrates the capability of the MPS-Db in early safety testing using a human liver MPS to relate the effects of tolcapone and entacapone in the in vitro model to human in

SUBMITTER: Gough A 

PROVIDER: S-EPMC5119471 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature