Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release.

ABSTRACT: Long-term changes of neurotransmitter release are critical for proper brain function. However, the molecular mechanisms underlying these changes are poorly understood. While protein synthesis is crucial for the consolidation of postsynaptic plasticity, whether and how protein synthesis regulates presynaptic plasticity in the mature mammalian brain remain unclear. Here, using paired whole-cell recordings in rodent hippocampal slices, we report that presynaptic protein synthesis is required for long-term, but not short-term, plasticity of GABA release from type 1 cannabinoid receptor (CB₁)-expressing axons. This long-term depression of inhibitory transmission (iLTD) involves cap-dependent protein synthesis in presynaptic interneuron axons, but not somata. Translation is required d

SUBMITTER: Younts TJ 

PROVIDER: S-EPMC5119541 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature