Poxvirus uracil-DNA glycosylase-An unusual member of the family I uracil-DNA glycosylases.

ABSTRACT: Uracil-DNA glycosylases are ubiquitous enzymes, which play a key role repairing damages in DNA and in maintaining genomic integrity by catalyzing the first step in the base excision repair pathway. Within the superfamily of uracil-DNA glycosylases family I enzymes or UNGs are specific for recognizing and removing uracil from DNA. These enzymes feature conserved structural folds, active site residues and use common motifs for DNA binding, uracil recognition and catalysis. Within this family the enzymes of poxviruses are unique and most remarkable in terms of amino acid sequences, characteristic motifs and more importantly for their novel non-enzymatic function in DNA replication. UNG of vaccinia virus, also known as D4, is the most extensively characterized UNG of the poxvirus family. D4 fo

SUBMITTER: Schormann N 

PROVIDER: S-EPMC5119566 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature