Neurobehavioral markers of resilience to depression amongst adolescents exposed to child abuse.

ABSTRACT: Childhood maltreatment is strongly associated with depression, which is characterized by reduced reactivity to reward. Identifying factors that mitigate risk for depression in maltreated children is important for understanding etiological links between maltreatment and depression as well as improving early intervention and prevention. We examine whether high reward reactivity at behavioral and neurobiological levels is a marker of resilience to depressive symptomology in adolescence following childhood maltreatment. A sample of 59 adolescents (21 with a history of maltreatment; Mean Age = 16.95 years, SD = 1.44) completed an fMRI task involving passive viewing of emotional stimuli. BOLD signal changes to positive relative to neutral images were extracted in basal ganglia regions of interes

SUBMITTER: Dennison MJ 

PROVIDER: S-EPMC5119749 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature