Ontology highlight
ABSTRACT:
SUBMITTER: Liu F
PROVIDER: S-EPMC5119773 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Cell 20161013 3
tRNA is a central component of protein synthesis and the cell signaling network. One salient feature of tRNA is its heavily modified status, which can critically impact its function. Here, we show that mammalian ALKBH1 is a tRNA demethylase. It mediates the demethylation of N<sup>1</sup>-methyladenosine (m<sup>1</sup>A) in tRNAs. The ALKBH1-catalyzed demethylation of the target tRNAs results in attenuated translation initiation and decreased usage of tRNAs in protein synthesis. This process is d ...[more]