Enterovirus D68 in Hospitalized Children: Sequence Variation, Viral Loads and Clinical Outcomes.

ABSTRACT:

Background

An outbreak of enterovirus D68 (EV-D68) caused severe respiratory illness in 2014. The disease spectrum of EV-D68 infections in children with underlying medical conditions other than asthma, the role of EV-D68 loads on clinical illness, and the variation of EV-D68 strains within the same institution over time have not been described. We sought to define the association between EV-D68 loads and sequence variation, and the clinical characteristic in hospitalized children at our institution from 2011 to 2014.

Methods

May through November 2014, and August to September 2011 to 2013, a convenience sample of nasopharyngeal specimens from children with rhinovirus (RV)/EV respiratory infections were tested for EV-D68 by RT-PCR. Clinical data were compared between children

SUBMITTER: Moyer K 

PROVIDER: S-EPMC5119825 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature