Skewed Lung CCR4 to CCR6 CD4⁺ T Cell Ratio in Idiopathic Pulmonary Fibrosis Is Associated with Pulmonary Function.

ABSTRACT:

Rationale

Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease. While it has been suggested that T cells may contribute to IPF pathogenesis, these studies have focused primarily on T cells outside of the pulmonary interstitium. Thus, the role of T cells in the diseased lung tissue remains unclear.

Objective

To identify whether specific CD4⁺ T cell subsets are differentially represented in lung tissue from patients with IPF.

Methods

CD4⁺ T cell subsets were measured in lung tissue obtained from patients with IPF at the time of lung transplantation, and from age- and gender-matched organ donors with no known lung disease. Subsets were identified by their surface expression of CCR4, CCR6, and CXCR3 chemokine receptors. CD4^+<

SUBMITTER: Adegunsoye A 

PROVIDER: S-EPMC5120085 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature