Altered Insular Function during Aberrant Salience Processing in Relation to the Severity of Psychotic Symptoms.

ABSTRACT: There is strong evidence for abnormal salience processing in patients with psychotic experiences. In particular, there are indications that the degree of aberrant salience processing increases with the severity of positive symptoms. The aim of the present study was to elucidate this relationship by means of brain imaging. Functional magnetic resonance imaging was acquired to assess hemodynamic responses during the Salience Attribution Test, a paradigm for reaction time that measures aberrant salience to irrelevant stimulus features. We included 42 patients who were diagnosed as having a psychotic disorder and divided them into two groups according to the severity of their positive symptoms. Whole brain analysis was performed using Statistical Parametric Mapping. We found no significant beh

SUBMITTER: Walter A 

PROVIDER: S-EPMC5120113 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature