Parallel pathways from whisker and visual sensory cortices to distinct frontal regions of mouse neocortex.

ABSTRACT: The spatial organization of mouse frontal cortex is poorly understood. Here, we used voltage-sensitive dye to image electrical activity in the dorsal cortex of awake head-restrained mice. Whisker-deflection evoked the earliest sensory response in a localized region of primary somatosensory cortex and visual stimulation evoked the earliest responses in a localized region of primary visual cortex. Over the next milliseconds, the initial sensory response spread within the respective primary sensory cortex and into the surrounding higher order sensory cortices. In addition, secondary hotspots in the frontal cortex were evoked by whisker and visual stimulation, with the frontal hotspot for whisker deflection being more anterior and lateral compared to the frontal hotspot evoked by visual stimul

SUBMITTER: Sreenivasan V 

PROVIDER: S-EPMC5120210 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature