Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials.

ABSTRACT: Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells (MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in

SUBMITTER: Labrador-Velandia S 

PROVIDER: S-EPMC5120242 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature