High Energy Particle Radiation-associated Oncogenic Transformation in Normal Mice: Insight into the Connection between Activation of Oncotargets and Oncogene Addiction.

ABSTRACT: Concerns on high-energy particle radiation-induced tumorigenic transformation of normal tissue in astronauts, and in cancer patients undergoing radiotherapy, emphasizes the significance of elucidating the mechanisms involved in radiogenic transformation processes. Mostly used genetically modified or tumor-prone models are less reliable in determining human health risk in space or protracted post-treatment normal tissue toxicity. Here, in wild type C57BL/6 mice, we related the deregulation of distinctive set of tissue-specific oncotargets in major organs upon ⁵⁶Fe (600 MeV/amu; 0.5 Gy/min; 0.8 Gy) particle radiation and compared the response with low LET γ-radiation (¹³⁷Cs; 0.5 Gy/min; 2 Gy). One of the novel findings is the 'tissue-independent' activation of TAL2 upon

SUBMITTER: Aravindan N 

PROVIDER: S-EPMC5120307 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature