Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights.

ABSTRACT: Gliomas are highly invasive brain tumours characterised by poor prognosis and limited response to therapy. There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies involve tumour blood vessel deterioration and normalisation. The former aims at tumour infarction and nutrient deprivation induced by blood vessel occlusion/collapse. In contrast, the therapeutic intention of normalising the abnormal tumour vasculature is to improve the efficacy of conventional treatment modalities. Although these strategies have shown therapeutic potential, it remains unclear why they both often fail to control glioma growth. To shed some light on this issue, we propose a mathematical model based on the migration/

SUBMITTER: Alfonso JC 

PROVIDER: S-EPMC5120360 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature