Sensory Conflict Disrupts Activity of the Drosophila Circadian Network.

ABSTRACT: Periodic changes in light and temperature synchronize the Drosophila circadian clock, but the question of how the fly brain integrates these two input pathways to set circadian time remains unanswered. We explore multisensory cue combination by testing the resilience of the circadian network to conflicting environmental inputs. We show that misaligned light and temperature cycles can lead to dramatic changes in the daily locomotor activities of wild-type flies during and after exposure to sensory conflict. This altered behavior is associated with a drastic reduction in the amplitude of PERIOD (PER) oscillations in brain clock neurons and desynchronization between light- and temperature-sensitive neuronal subgroups. The behavioral disruption depends heavily on the phase relationship between

SUBMITTER: Harper REF 

PROVIDER: S-EPMC5120367 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature