Functional and Genomic Features of Human Genes Mutated in Neuropsychiatric Disorders.

ABSTRACT:

Background

In recent years, a large number of studies around the world have led to the identification of causal genes for hereditary types of common and rare neurological and psychiatric disorders.

Objective

To explore the functional and genomic features of known human genes mutated in neuropsychiatric disorders.

Methods

A systematic search was used to develop a comprehensive catalog of genes mutated in neuropsychiatric disorders (NPD). Functional enrichment and protein-protein interaction analyses were carried out. A false discovery rate approach was used for correction for multiple testing.

Results

We found several functional categories that are enriched among NPD genes, such as gene ontologies, protein domains, tissue expression, signaling pathways and regul

SUBMITTER: Forero DA 

PROVIDER: S-EPMC5120378 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature