Identification of the transcripts associated with spontaneous HCV clearance in individuals co-infected with HIV and HCV.

ABSTRACT:

Background

Infection with human immunodeficiency virus (HIV) influences the outcome and natural disease progression of hepatitis C virus (HCV) infection. While the majority of HCV mono-infected and HCV/HIV co-infected subjects develop chronic HCV infection, 20-46% of mono- and co-infected subjects spontaneously clear HCV infection. The mechanism underlying viral clearance is not clearly understood. Analysis of differential cellular gene expression (mRNA) between HIV-infected patients with persistent HCV infection or spontaneous clearance could provide a unique opportunity to decipher the mechanism of HCV clearance.

Methods

Plasma RNA from HIV/HCV co-infected subjects who cleared HCV and those who remained chronically infected with HCV was sequenced using Ion Torrent technolo

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5120459 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature