A transcriptome-based model of central memory CD4 T cell death in HIV infection.

ABSTRACT:

Background

Human central memory CD4 T cells are characterized by their capacity of proliferation and differentiation into effector memory CD4 T cells. Homeostasis of central memory CD4 T cells is considered a key factor sustaining the asymptomatic stage of Human Immunodeficiency Virus type 1 (HIV-1) infection, while progression to acquired immunodeficiency syndrome is imputed to central memory CD4 T cells homeostatic failure. We investigated if central memory CD4 T cells from patients with HIV-1 infection have a gene expression profile impeding proliferation and survival, despite their activated state.

Methods

Using gene expression microarrays, we analyzed mRNA expression patterns in naive, central memory, and effector memory CD4 T cells from healthy controls, and naive and

SUBMITTER: Olvera-Garcia G 

PROVIDER: S-EPMC5120471 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature