Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data.

ABSTRACT:

Background

Next-generation sequencing (NGS) informs many biological questions with unprecedented depth and nucleotide resolution. These assays have created a need for analytical tools that enable users to manipulate data nucleotide-by-nucleotide robustly and easily. Furthermore, because many NGS assays encode information jointly within multiple properties of read alignments - for example, in ribosome profiling, the locations of ribosomes are jointly encoded in alignment coordinates and length - analytical tools are often required to extract the biological meaning from the alignments before analysis. Many assay-specific pipelines exist for this purpose, but there remains a need for user-friendly, generalized, nucleotide-resolution tools that are not limited to specific experimental

SUBMITTER: Dunn JG 

PROVIDER: S-EPMC5120557 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature