Micro-CT vs. Whole Body Multirow Detector CT for Analysing Bone Regeneration in an Animal Model.

ABSTRACT:

Objectives

Compared with multirow detector CT (MDCT), specimen (ex vivo) micro-CT (μCT) has a significantly higher (~ 30 x) spatial resolution and is considered the gold standard for assessing bone above the cellular level. However, it is expensive and time-consuming, and when applied in vivo, the radiation dose accumulates considerably. The aim of this study was to examine whether the lower resolution of the widely used MDCT is sufficient to qualitatively and quantitatively evaluate bone regeneration in rats.

Methods

Forty critical-size defects (5mm) were placed in the mandibular angle of rats and covered with coated bioactive titanium implants to promote bone healing. Five time points were selected (7, 14, 28, 56 and 112 days). μCT and MDCT were used to evaluate the defect

SUBMITTER: Bissinger O 

PROVIDER: S-EPMC5120815 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature