Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Q
PROVIDER: S-EPMC5120857 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Zhao Quan Q Rank Gerhard G Tan Yuen T YT Li Haitao H Moritz Robert L RL Simpson Richard J RJ Cerruti Loretta L Curtis David J DJ Patel Dinshaw J DJ Allis C David CD Cunningham John M JM Jane Stephen M SM
Nature structural & molecular biology 20090222 3
Mammalian gene silencing is established through methylation of histones and DNA, although the order in which these modifications occur remains contentious. Using the human beta-globin locus as a model, we demonstrate that symmetric methylation of histone H4 arginine 3 (H4R3me2s) by the protein arginine methyltransferase PRMT5 is required for subsequent DNA methylation. H4R3me2s serves as a direct binding target for the DNA methyltransferase DNMT3A, which interacts through the ADD domain containi ...[more]