Human papillomavirus-related esophageal cancer survival: A systematic review and meta-analysis.

ABSTRACT:

Background

Human papillomavirus (HPV) has been identified to be related to progression of esophageal cancer. However, the results remain controversial. A meta-analysis of epidemiologic studies was therefore conducted to address this issue.

Methods

The electronic databases of MEDLINE and Excerpta Medica database were searched till April 30, 2016. Study-specific risk estimates were pooled using a random-effects model.

Results

Ten studies involving a total of 1184 esophageal cancer cases were included in this meta-analysis. The pooled hazard ratio comparing HPV-positive to HPV-negative esophageal cancers was 1.03 (95% confidence interval 0.78-1.37), which was not significantly correlated with improved survival. However, HPV-16-positive patients might have a significantly

SUBMITTER: Guo L 

PROVIDER: S-EPMC5120915 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature