Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa.

ABSTRACT:

Background

Weight loss may decrease risk of colorectal cancer in obese individuals, yet its effect in the colorectum is not well understood. We used integrative network modeling, Passing Attributes between Networks for Data Assimilation, to estimate transcriptional regulatory network models from mRNA expression levels from rectal mucosa biopsies measured pre- and post-weight loss in 10 obese, pre-menopausal women.

Results

We identified significantly greater regulatory targeting of glucose transport pathways in the post-weight loss regulatory network, including "regulation of glucose transport" (FDR=0.02), "hexose transport" (FDR=0.06), "glucose transport" (FDR=0.06) and "monosaccharide transport" (FDR=0.08). These findings were not evident by gene expression analysis alone.

SUBMITTER: Vargas AJ 

PROVIDER: S-EPMC5121035 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature