Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program.

ABSTRACT:

Objective

We examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations.

Methods

The study was conducted in the placebo (n = 1082) and intensive lifestyle (n = 1079) groups of the Diabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (n = 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1.

Results

In cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustm

SUBMITTER: Ceglia L 

PROVIDER: S-EPMC5121080 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature