Glaucoma Risk Alleles in the Ocular Hypertension Treatment Study.

ABSTRACT:

Purpose

Primary open-angle glaucoma (POAG) is a major cause of blindness and visual disability. Several genetic risk factors for POAG and optic nerve features have been identified. We measured the relative risk for glaucoma that these factors contribute to participants in the Ocular Hypertension Treatment Study (OHTS).

Design

Comparative series.

Participants

One thousand fifty-seven of 1636 participants (65%) of the OHTS were enrolled in this genetics ancillary study.

Methods

Samples of DNA were available from 1057 OHTS participants. Of these, 209 developed POAG (cases) and 848 did not develop glaucoma (controls) between 1994 and 2009. The frequencies of 13 risk alleles previously associated with POAG or with optic disc features in other cohorts were compared b

SUBMITTER: Scheetz TE 

PROVIDER: S-EPMC5121091 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature