Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways.

ABSTRACT: A number of emerging studies suggest that air pollutants such as hydrogen sulfide (H₂S) and ammonia (NH₃) may cause a decline in spermatozoa motility. The impact and underlying mechanisms are currently unknown. Boar spermatozoa (in vitro) and peripubertal male mice (in vivo) were exposed to H₂S and/or NH₃ to evaluate the impact on spermatozoa motility. Na₂S and/or NH₄Cl reduced the motility of boar spermatozoa in vitro. Na₂S and/or NH₄Cl disrupted multiple signaling pathways including decreasing Na⁺/K⁺ ATPase activity and protein kinase B (AKT) levels, activating Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) and phosphatase and tensin homolog deleted on chromosom

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC5121643 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature