Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children.

ABSTRACT:

Background

We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts.

Materials and methods

Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed.

Results

Genotype consistency was not statistically significant in both C677T and A1298C gene variants (P > 0.05).

Conclusion

Maternal folic acid consumption may not have any significant effect on modifying C677T and A1298C polymorphisms in children.

SUBMITTER: Ebadifar A 

PROVIDER: S-EPMC5121989 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature