BoHV-4-based vector delivering Ebola virus surface glycoprotein.

ABSTRACT:

Background

Ebola virus (EBOV) is a Category A pathogen that is a member of Filoviridae family that causes hemorrhagic fever in humans and non-human primates. Unpredictable and devastating outbreaks of disease have recently occurred in Africa and current immunoprophylaxis and therapies are limited. The main limitation of working with pathogens like EBOV is the need for costly containment. To potentiate further and wider opportunity for EBOV prophylactics and therapies development, innovative approaches are necessary.

Methods

In the present study, an antigen delivery platform based on a recombinant bovine herpesvirus 4 (BoHV-4), delivering a synthetic EBOV glycoprotein (GP) gene sequence, BoHV-4-syEBOVgD106ΔTK, was generated.

Results

EBOV GP was abundantly expressed by

SUBMITTER: Rosamilia A 

PROVIDER: S-EPMC5122150 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature