Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC5122381 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Wu Chenglin C de Miranda Noel Fcc NF Chen Longyun L Wasik Agata M AM Mansouri Larry L Jurczak Wojciech W Galazka Krystyna K Dlugosz-Danecka Monika M Machaczka Maciej M Zhang Huilai H Peng Roujun R Morin Ryan D RD Rosenquist Richard R Sander Birgitta B Pan-Hammarström Qiang Q
Oncotarget 20160601 25
The genetic mechanisms underlying disease progression, relapse and therapy resistance in mantle cell lymphoma (MCL) remain largely unknown. Whole-exome sequencing was performed in 27 MCL samples from 13 patients, representing the largest analyzed series of consecutive biopsies obtained at diagnosis and/or relapse for this type of lymphoma. Eighteen genes were found to be recurrently mutated in these samples, including known (ATM, MEF2B and MLL2) and novel mutation targets (S1PR1 and CARD11). CAR ...[more]