Functional/activity network (FAN) analysis of gene-phenotype connectivity liaised by grape polyphenol resveratrol.

ABSTRACT: Resveratrol is a polyphenol that has witnessed an unprecedented yearly growth in PubMed citations since the late 1990s. Based on the diversity of cellular processes and diseases resveratrol reportedly affects and benefits, it is likely that the interest in resveratrol will continue, although uncertainty regarding its mechanism in different biological systems remains.We hypothesize that insights on disease-modulatory activities of resveratrol might be gleaned by systematically dissecting the publicly available published data on chemicals and drugs. In this study, we tested our hypothesis by querying DTome (Drug-Target Interactome), a web-based tool containing data compiled from open-source databases including DrugBank, PharmGSK, and Protein Interaction Network Analysis (PINA). Four direct p

SUBMITTER: Hsieh TC 

PROVIDER: S-EPMC5122419 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature