Perspectives for immunotherapy: which applications might achieve an HIV functional cure?

ABSTRACT: The major advances achieved in devising successful combined antiretroviral therapy (cART) have enabled the sustained control of HIV replication. However, this is associated with costly lifelong treatment, partial immune restoration, chronic inflammation and persistent viral reservoirs. In this context, new therapeutic strategies deserve investigation as adjuncts to cART so as to potentiate immune responses that are capable of completely containing HIV pathogenicity, particularly if cART is discontinued. This may seem a dauntingly high hurdle given the results to date. This review outlines the key research efforts that have recently resurrected immunotherapeutic options, and some of the approaches tested to date. These areas include promising cytokines or vaccine strategies, using different

SUBMITTER: Vieillard V 

PROVIDER: S-EPMC5122442 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature