Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.

ABSTRACT:

Purpose

Wilms' tumor (WT), the most common pediatric renal malignancy, is associated with mutations in several well-characterized genes, most notably WT1, CTNNB1, WTX, and TP53. However, the majority of cases do not harbor mutations in these genes. We hypothesized that additional drivers of tumor behavior would be contained within areas of consistent genomic copy number change, especially those associated with the WT risk groups defined by the International Society of Paediatric Oncology (SIOP).

Experimental design

We analyzed high-resolution (Affymetrix 250K single nucleotide polymorphism array) genomic copy number profiles of over 100 tumors from selected risk groups treated under the SIOP protocols, further characterizing genes of interest by sequencing, Multiplex Ligatio

SUBMITTER: Williams RD 

PROVIDER: S-EPMC5122447 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature