Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study.

ABSTRACT:

Objective

The mechanism causing gastrointestinal intolerance to metformin treatment is unknown. We have previously shown that reduced-function alleles of organic cation transporter 1 (OCT1) are associated with increased intolerance to metformin. Considering recent findings that serotonin reuptake transporter (SERT) might also be involved in metformin intestinal absorption, and the role of serotonin in gastrointestinal physiology, in this study we investigated the association between a common polymorphism in the SERT gene and metformin gastrointestinal intolerance.

Research design and methods

We explored the effect of composite SERT 5-HTTLPR/rs25531 genotypes, L*L* (L_AL_A), L*S* (L_AL_G, L_AS), and S*S* (SS, SL_G, L

SUBMITTER: Dujic T 

PROVIDER: S-EPMC5122449 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature