Effect of Continuous Positive Airway Pressure on Airway Reactivity in Asthma. A Randomized, Sham-controlled Clinical Trial.

ABSTRACT:

Rationale

Studies have demonstrated that application of stress suppresses airway smooth muscle contractility. In animal models of asthma, continuous positive airway pressure (CPAP) reduced airway reactivity. Short-term studies of CPAP in patients with asthma showed reductions in airway reactivity.

Objectives

To evaluate whether nocturnal CPAP decreased the provocative concentration of methacholine to reduce FEV₁ by 20% (PC₂₀).

Methods

One hundred ninety-four individuals with asthma were randomized (1:1:1) to use CPAP with warmed, filtered, humidified air at night at pressures either less than 1 cm H₂O (sham) or at 5 cm H₂O or 10 cm H₂O. The primary outcome was change in PC₂₀ after 12 weeks.

Measureme

SUBMITTER: Holbrook JT 

PROVIDER: S-EPMC5122477 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature