The Retinome - defining a reference transcriptome of the adult mammalian retina/retinal pigment epithelium.

ABSTRACT:

Background

The mammalian retina is a valuable model system to study neuronal biology in health and disease. To obtain insight into intrinsic processes of the retina, great efforts are directed towards the identification and characterization of transcripts with functional relevance to this tissue.

Results

With the goal to assemble a first genome-wide reference transcriptome of the adult mammalian retina, referred to as the retinome, we have extracted 13,037 non-redundant annotated genes from nearly 500,000 published datasets on redundant retina/retinal pigment epithelium (RPE) transcripts. The data were generated from 27 independent studies employing a wide range of molecular and biocomputational approaches. Comparison to known retina-/RPE-specific pathways and established re

SUBMITTER: Schulz HL 

PROVIDER: S-EPMC512282 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature