Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger.

ABSTRACT:

Importance

Young febrile infants are at substantial risk of serious bacterial infections; however, the current culture-based diagnosis has limitations. Analysis of host expression patterns ("RNA biosignatures") in response to infections may provide an alternative diagnostic approach.

Objective

To assess whether RNA biosignatures can distinguish febrile infants aged 60 days or younger with and without serious bacterial infections.

Design, setting, and participants

Prospective observational study involving a convenience sample of febrile infants 60 days or younger evaluated for fever (temperature >38° C) in 22 emergency departments from December 2008 to December 2010 who underwent laboratory evaluations including blood cultures. A random sample of infants with and witho

SUBMITTER: Mahajan P 

PROVIDER: S-EPMC5122927 | biostudies-literature | 2016 Aug 23-30

REPOSITORIES: biostudies-literature