Family-based clusters of cognitive test performance in familial schizophrenia.

ABSTRACT:

Background

Cognitive traits derived from neuropsychological test data are considered to be potential endophenotypes of schizophrenia. Previously, these traits have been found to form a valid basis for clustering samples of schizophrenia patients into homogeneous subgroups. We set out to identify such clusters, but apart from previous studies, we included both schizophrenia patients and family members into the cluster analysis. The aim of the study was to detect family clusters with similar cognitive test performance.

Methods

Test scores from 54 randomly selected families comprising at least two siblings with schizophrenia spectrum disorders, and at least two unaffected family members were included in a complete-linkage cluster analysis with interactive data visualization.

SUBMITTER: Hoti F 

PROVIDER: S-EPMC512293 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature