Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease.

ABSTRACT: Intestinal microbial dysbiosis is associated with Crohn's disease (CD). However, the mechanisms leading to the chronic mucosal inflammation that characterizes this disease remain unclear. In this report, we use systems-level approaches to study the interactions between the gut microbiota and host in new-onset paediatric patients to evaluate causality and mechanisms of disease. We report an altered host proteome in CD patients indicative of impaired mitochondrial functions. In particular, mitochondrial proteins implicated in H₂S detoxification are downregulated, while the relative abundance of H₂S microbial producers is increased. Network correlation analysis reveals that Atopobium parvulum controls the central hub of H₂S producers. A. parvulum induces panco

SUBMITTER: Mottawea W 

PROVIDER: S-EPMC5122959 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature