Prognostic value of inflammation in prostate cancer progression and response to therapeutic: a critical review.

ABSTRACT: Prostate is an immune-competent organ normally populated by inflammatory cells. Prostatic inflammation origin can be multi-factorial and there are some emerging evidences on its possible role as a factor involved in prostate cancer (PC) pathogenesis and progression. This review critically analyzes the role of inflammation as a prognostic factor for progression and aggressiveness of PC. We verified the last 10 years literature data on the association between inflammation and PC aggressiveness, or PC response to therapies. Several studies tried to correlate different inflammatory factors with the aggressiveness and metastatization of PC; all data sustain the role of inflammation in PC progression but they also produce confusion to identify a reliable clinical prognostic marker. Data on patie

SUBMITTER: Sciarra A 

PROVIDER: S-EPMC5123292 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature