Cancer somatic mutations cluster in a subset of regulatory sites predicted from the ENCODE data.

ABSTRACT:

Background

Transcriptional regulation of gene expression is essential for cellular differentiation and function, and defects in the process are associated with cancer. The ENCODE project has mapped potential regulatory sites across the complete genome in many cell types, and these regions have been shown to harbour many of the somatic mutations that occur in cancer cells, suggesting that their effects may drive cancer initiation and development. The ENCODE data suggests a very large number of regulatory sites, and methods are needed to identify those that are most relevant and to connect them to the genes that they control.

Methods

Predictive models of gene expression were developed by integrating the ENCODE data for regulation, including transcription factor binding and DNa

SUBMITTER: Shar NA 

PROVIDER: S-EPMC5123355 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature